Educational Qualifications

Ph.D. (Pharmaceutical Chemistry)

Area of Specialization / Research

Designing, synthesis, and characterization of new chemical entities incorporating heterocyclic scaffolds as potential anti-inflammatory (COX-1, COX-2 & ITK inhibitors), Anti-Alzheimer & Anticancer (ALK & PD-L1 Inhibitors) agents. Development and validation of analytical methods for drugs and drug formulations.

Notable Publications

1. 1.

   Verma S, Tonk RK , Albratty M, Alhazmi HA, Najmi A, Kumar R, Kumar M, Taleuzzaman M, Swami G, Alam, MS. Design and evaluation of sustained release mucoadhesive film of sumatriptan succinate containing grafted co-polymer as the platform, Saudi Pharmaceutical Journal (2022), doi: https://doi.org/10.1016/j.jsps.2022.07.014 IF 4.56

   2022
2. 2.

   Munjal Y, Tonk RK , Sharma R. Analytical Techniques Used in Metabolomics: A Review. Sys Rev Pharm 2022; 13(5): 550-556.

   2022
3. 3.

   Mittal L, Tonk R , Awasthi A, Asthana S. Traversing through the Dynamic Protein–Protein Interaction Landscape and Conformational Plasticity of PD-1 for Small-Molecule Discovery. Journal of Medicinal Chemistry. 2022; 65(8): 5941-5953. IF 7.5

   2022
4. 4.

   Gaur A and Tonk R . Covid-19 pandemic and digitalization of healthcare among youth: a marketing perspective. EPRA International Journal of Economics, Business and Management Studies (EBMS). 2021; 8(8): 52-60.

   2021
5. 5.

   Mittal L, Tonk RK , Awasthi, Asthana S. Targeting cryptic-orthosteric site of PD-L1 for inhibitor identification using structure-guided approach, Archives of Biochemistry and Biophysics. 2021; 713: 109059.

   2021
6. 6.

   Sharma P, Tonk RK , Malik M, Chaudhary V, Sharma S, Thukral N. The Effect of Space Microgravity on Knee Joint and its Rehabilitation. Turkish Journal of Physiotherapy and Rehabilitation. 2021; 32(3): 23101-23106.

   2021
7. 7.

   Kumar S, Tonk RK , Sharma PC. Some Quality Control Analysis Parameters for Parenteral Formulations. International Journal of Trend in Scientific Research and Development. 2021; 5(4): 944-948.

   2021
8. 8.

   Sharma D, Sharma V, Sharma A, Goyal R, Tonk RK , Thakur VK and Sharma PC. Green chemistry approaches for thiazole containing compounds as a potential scaffold for cancer therapy. Sustainable Chemistry and Pharmacy. 2021; 23:100496.

   2021
9. 9.

   Singh G, Pathania R, Khan M, Tonk RK , Kumar D and Dash AK. Identification and quantification of some natural compounds of Pinus gerardiana leaf extracts and its antimicrobial and antioxidant activities. Archives, 2021; Vol.2: 333-351.

   2021
10. 10.

    Mittal L, Srivastava M, Kumari A, Tonk RK , Awasthi A and Asthana S. Interplay among Structural Stability, Plasticity, and Energetics Determined by Conformational Attuning of Flexible Loops in PD-1. Journal of Chemical Information and Modeling. 2021; 61(1): 358– 384.

    2021
11. 11.

    Yadav V, Reang J, Sharma V, Majeed J, Jambulingam S, Goyal R, Tonk RK. Repositioning of Drugs as a promising strategy to fight COVID-19. Coronaviruses. 2021; 2: 1-15.

    2021
12. 12.

    Tonk RK , Yadav V, Hasan M. Efficient One-Pot Synthesis of 3-Substituted Phthalides via Additive Arylation of Organozinc Intermediate. Letters in Org Chem, 2021;18: 1-7. IF 0.7 13. Goyal RK, Majeed J, Tonk R , Dhobi M, Patel B, Sharma K, Apparsundaram S. Current targets and drug candidates for prevention and treatment of SARS-CoV-2 (COVID-19) infection.

    2021
13. 13.

    Singh RB; Fedacko Jan; Goyal RK; Rai RH; Nandave M; Tonk RK et al. Pathophysiology and Significance of Troponin T in Heart Failure, with Reference to Behavioral Risk Factors. World Heart Journal; Hauppauge 2020, 12 (1): 15-21.

    2020
14. 14.

    Vivek Yadav, Rajiv Kumar Tonk , Ramchander Khatri; Molecular Docking, 3D-QSAR, Fingerprint-Based 2D-QSAR Analysis of Pyrimidine Analogs of ALK (Anaplastic Lymphoma Kinase) Inhibitors as an Anticancer Agent. Letters in Drug Design; Discovery; DOI: 10.2174/1570180817999201123163617.
15. 15.

    Saini N, Sharma A, Thakur VK, Makatsoris H, Dandia A, Bhagat M, Tonk RK and Sharma PC. Microwave Assisted Green synthesis of Thiazolidin-4-One derivatives: A Perspective on Potent Antiviral and Antimicrobial Activities, Current Research in Green and Sustainable Chemistry. 2020; 3: 100021-26. https://doi.org/10.1016/j.crgsc.2020.10002. 17. Shikha Goswami, Ozaifa Kareem, Ramesh K Goyal, Sayed M Mumtaz, Rajiv K Tonk, Rahul Gupta, Faheem H Pottoo. Role of Forkhead Transcription Factors of the O Class (FoxO) in Development and Progression of Alzheimer’s disease; CNS Neurol Disord Drug Targets. 2020; 19(9):709-721. doi: 10.2174/1871527319666201001105553. 18. Mumtaz SM, Bhardwaj G, Tonk RK , Goyal RK, Pottoo FH. Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle Based Targeted Drug Delivery System. Current Drug Targets 2020; 21. DOI: 10.2174/1389450121666200727115454. IF 2.8

    2020
16. 16.

    Tonk RK , Bawa S, Kumar D, Therapeutic Potential of Cinnoline Core: A comprehensive review. Mini-Review in Med Chem. 2020;20(3):196-218. IF 3.0

    2020
17. 17.

    Tonk RK , Sahu K, et al, Method development and validation for detection of Procaterol in human urine using gas chromatography-Tandem Mass spec. IJPER 2020;54(1): 150-154. IF 0.5

    2020
18. 18.

    R. Tonk , Sharma P, et al, Use of current therapeutic devices in the treatment of restless legs syndrome: A review. Medico-Legal Update 2020;20(2):140-144. H. Index -08 22. Tonk RK , Biswas D, Patent grand on anticancer phytoconstituent in last five years (2014- 2018)-A Review. Int J Pharm and Bio Sci, 2019 , 9(3), 932-940. H. Index- 27 23. A Sharma, R Tonk , V Sharma, Liquid chromatography tandem mass spectrometry determination of prohibited diuretics and other acidic drugs in human urine: A Review, The Pharma Innovation Journal 2018 ; 7(7): 57-61. H. Index- 04

    2020
19. 19.

    Iontophoretic Treatment in Knee Osteoarthritis: Non-Pharmacological Therapy. Rajiv Tonk , Parul Sharma. Int J of Sci Engg Res. 2018 , Volume 9, Issue 7, 1823-1831, H. Index 04

    2018
20. 20.

    Active stretching of hip flexors increases hip extension range of motion more than passive stretching. Jain S, Bhat AM, Tonk RK. Int J Dev Res. 2018 ; 8 (3): 19654-659. H. Index – 17

    2018
21. 21.

    Amin H, Wakode S, Tonk RK. Synthesis, Characterization and Antimicrobial Activity of Morpholine Mannich Base Derivatives. Int J Pharm sci Res. 2018 ; 9 (7): 2760-2766. IF 1.81

    2018
22. 22.

    Amin H, T onk RK, Synthesis, Characterization and Antioxidant Activity of Morpholine Mannich Base Derivatives. Int J Curr Pharm Rev and Res. 2017 ; 8 (5): 354-360. H. Index 09

    2017
23. 23.

    Phenothiazines and related drugs as Multi Drug Resistance Reversal Agents in cancer chemotherapy mediated by p-glycoprotein. Current Cancer Therapy Reviews , 1: 13 (2017) , 28- 42. H. Index- 12

    2017
24. 24.

    An overview on Olmesarten. World Journal of Pharmaceutical Research, 6:15, (2017) , 423-448

    2017
25. 25.

    Feronia Limonia –A Wonder Drug. H. Amin, Dr. S. Wakode and Dr. R. K. Tonk, W.J.P. Pharma. Sci., 6: 4 (2017) , 1982-1994. IF- 0.63

    2017
26. 26.

    Synthesis and application of Thiobarbituric Acid Derivatives as antifungal agents. P. Rathee, R.K.Tonk et al , Cellular Molecular Biology , 62: 141 (2016) . IF- 0.60

    2016
27. 27.

    A review on anticancer potential of bioactive heterocycle quinoline. Obaid Afzal, Manu Jaggi, Rajiv Kumar et al . Eur J Med Chem , 97 (2015) , 871-910. IF- 5.57

    2015
28. 28.

    Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors. Obaid Afzal, Sandhya Bawa, Suresh Kumar, Rajiv Kumar et al. Bioorg Med Chem Lett , 24 (2014) 3986-96. IF – 2.8

    2014
29. 29.

    3D-QSAR study of benzotriazol-1-yl carboxamide scaffold as monoacylglycerol lipase inhibitors. Obaid Afzal, Rajiv Kumar, Sandhya Bawa. J Pharm Bioall Sci, 6 (2014), 260. H. Index 27

    2014
30. 30.

    Design, synthesis and evaluation of novel 2-piperidinyl quinoline chalcones/amines as potential antidepressants agents. Obaid Afzal, sandhya Bawa, Suresh Kumar, Rajiv Kumar et al . Lett in Drug Design Discovery , 10 (2013) , 75-85. IF – 0.87

    2013
31. 31.

    Child Resistant Packaging: A Prime Concern for Packaging of Medicinal Products, Sarika Malhotra, Rajiv K. Arora, Rajiv Tonk . Int J Pharmaceu Sci Rev Res , 22 (2013) 79-88. H. Index 16

    2013
32. 32.

    Pyrazole incorporated 1,2-diazanaphthalene derivatives: Synthesis and in-vivo pharmacological screening as anti-inflammatory and analgesic agents. Rajiv K. Tonk , Sandhya Bawa, Suresh Kumar et al . Afr J Pharm Pharmacol , 6 (2012) , 425-433. IF – 0.81

    2012
33. 33.

    Synthesis and pharmacological evaluation of pyrazolo[4,3- c ]cinnoline derivatives as potential anti inflammatory and antibacterial agents. Rajiv K. Tonk , Sandhya Bawa, Gita Chawla, Suresh Kumar et al . Eur J Med Chem , 57 (2012) , 176-184. IF- 5.57

    2012
34. 34.

    N-([2-(Piperidin-1-yl)quinolin-3-yl]methylene)pyridine-4-carbohydrazide. Obaid Afzal, Sandhya Bawa, Suresh Kumar and Rajiv K. Tonk. Molbank, M748, (2012) . IF- 0.25

    2012
35. 35.

    1-(8-Chloro-3-methyl-1 H -pyrazolo[4,3- c ]cinnolin-1-yl)-2-(2-chlorophenyl)ethanone. S. Bawa, Rajiv Kumar et al . Molbank, M744, ( 2011) . doi:10.3390/M744. IF- 0.5

    2011
36. 36.

    Synthesis, antidepressant antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives. S. Kumar, R. Kumar et al . Eur J Med Chem , 46 (2011), 670-75. I F – 5.57 42. Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review. S. Bawa, Rajiv Kumar et al. J Pharm Bioall Sci, 2 ( 2011 ), 194-212. H. Index 27 43. (8-Chloro-3-methyl-1 H -pyrazolo[4,3- c ]cinnolin-1-yl) (pyridin-4-yl) methanone. S. Bawa, Rajiv Kumar , G. Chawla, S. Kumar and R. Mishra. Molbank, M688, (2010) . IF- 0.5 44. Synthesis and in-vivo anticonvulsant evaluation of 2-chloroquinolinyl–hydrazone Derivatives. Suresh Kumar, Sandhya Bawa, Sushma Drabu, Rajiv Kumar , Lalit Machawal. Acta Pol Pharmaceu-Drug Res , 67 (2010) , 567-573. IF – 0.87

    2011
37. 37.

    New 2-chloro-7-methylquinoline amine analogues as possible antimycotic agents. Sandhya Bawa, Rajiv Kumar et al . Lat Amer J Pharm, 29 (2010) , 968-975. IF- 0.40

    2010
38. 38.

    6-Oxo-3-phenyl-5,6-dihydropyridazine-1(4 H )-carbohydrazide. Ravinesh Mishra, Anees Ahmed Siddiqui, Rajiv Kumar and Suresh Kumar. Short note. Molbank. M652, ( 2010) . IF- 0.5 47. Structural modifications of quinoline- based antimalarial agents: recent developments. Sandhya Bawa, Suresh Kumar, Rajiv Kumar . J Pharm Bioall Sci, 2 (2010) , 64-71. H. Index 27 48. Career opportunities in pharmacy profession: An informative note. Sandhya Bawa, Rajiv K. Tonk , Jyoti A. Tonk, Suresh Kumar, Sumit Singla. Chronicles of Young Scientists , 1 (2010) 7-11. H. Index-08

    2010
39. 39.

    Synthesis, Spectral characterization and pharmacological screening of some 4-[(1- (aryl) methylidine)-amino]-3-(4-pyridyl)-5-mercapto-4 H -1,2,4-triazole derivatives. Anees A. Siddiqui, Rajiv Kumar et al . Journal of Pharmacy and Bioallied Sciences . 2 ( 2010 ) 109-112. H. Index 27

    2010
40. 40.

    Synthesis and in vitro antimicrobial activity of some triazole derivatives. Ravinesh Mishra, Rajiv Kumar , Suresh Kumar et al . J of the Chilean Chem Soc, 55 (2010) , 283-286. IF – 0.45 51. Synthesis and antimicrobial activity of 2-chloro-6-methylquinoline hydrazone derivatives. S. Bawa, Rajiv Kumar et al. Journal of Pharmacy and Bioallied Sciences. 1 (2009) 27-31. H. Index 27 52. Biological Activities of Pyrazoline Derivatives -A Recent Development. Sandhya Bawa, Rajiv Kumar et al . Rec Patents on Anti-Infec Drug Discov , 4 (2009) , 154-163. H. Index 23 53. Synthesis and antimicrobial activity of 2-Chloroquinoline incorporated pyrazoline derivatives. Sandhya Bawa, Rajiv Kumar et al. J Pharm Bioall Sci, 1 (2009) , 32-36. H. Index 27

    2010

Awards & Achievements

• Three Notable Research Awards and Cash Prize of ₹4028 – 1st Research Promotion Award Ceremony, DPSRU

  2022

• Appreciation Award from Mrs. Seema Trikha, Chairperson, Haryana Education Committee (MLA Badkhal)

  2020

• Appreciation Award from Deputy Chief Minister Delhi, Shri Manish Sisodia – for excellent academic and administrative work during session 2019-20

  2020

• Appreciation Award by Airports Authority of India (AAI) and Central Vigilance Commission (CVC) during Vigilance Awareness Week

• Certificate of Appreciation from Vice Chancellor, DPSRU – for improvement in online admissions

• Certificate of Appreciation from Vice Chancellor, DPSRU – for outstanding services related to students affairs, B.P.T. computer sanction follow up (2016-17)

  2017

• CSIR Foreign Travel Grant – to present paper at "Structural & Computational Chemistry 2012, Germany"

  2012

• Certificate of Recognition and Cash Prize ₹5000 – for Ph.D. research and publication in high impact factor journal (EJMC)

  2012

• 1st Prize – Oral Paper Presentation, AICTE-sponsored National Seminar, MSIP New Delhi

  2011

• 1st Prize – Poster Presentation, National Seminar on "Emerging Trends in Pharmaceutical Sciences", Faculty of Pharmacy, Jamia Hamdard

  2009

• UGC-RGN Junior & Senior Research Fellowship (2008-2012)

  2008

• AICTE-GATE Fellowship during M.Pharmacy (2005-2007)

  2005